Rapid expansion of highly functional antigen-specific T cells from patients with melanoma by nanoscale artificial antigen-presenting cells

J Ichikawa, T Yoshida, A Isser, AS Laino… - Clinical Cancer …, 2020 - AACR
… Combined, these cellular attributes characterize T cells with antitumor properties that may
… IL4, IL5, and IL13 were detected in response to peptide-pulsed T2 cells but not to control T2 …

Selective STING stimulation in dendritic cells primes antitumor T cell responses

B Jneid, A Bochnakian, C Hoffmann, F Delisle… - Science …, 2023 - science.org
… strategy to enhance T celltargeted immunotherapy. … of synthetic CDNs that activate STING
stimulates antitumor … into the induction of IFNs by antigen-presenting cells, we treated bone …

Immunotherapy targeting tumor‐associated antigen in a mouse model of head and neck cancer

…, T Kumai, H Yamaki, R Sato, T Nagato, T Ohkuri… - Head & …, 2024 - Wiley Online Library
… -specific T cell responses in a non-artificial mouse model. … recognized by T cells in the context
of antigen-presenting molecules… with CD4 + T cell-targeted vaccine shows better antitumor

[HTML][HTML] Recent advances in antigen targeting to antigen-presenting cells in veterinary medicine

EA Melgoza-González, L Bustamante-Córdova… - Frontiers in …, 2023 - frontiersin.org
… Different approaches using antibodies, natural or synthetic ligands… effectively elicited a robust
and protective immune response … as a model to elicit an antitumoral response in dogs. The …

Bioinspired vaccines to enhance MHC class-I antigen cross-presentation

JJ Baljon, JT Wilson - Current opinion in immunology, 2022 - Elsevier
synthetic vaccines can be engineered to enhance MHC-I presentation of exogenous peptide
and protein antigens by professional antigen-presenting cells (… + T celltargeted vaccines. …

Intranasal delivery of cationic liposome-protamine complex mRNA vaccine elicits effective anti-tumor immunity

Y Mai, J Guo, Y Zhao, S Ma, Y Hou, J Yang - Cellular Immunology, 2020 - Elsevier
… Immunization with synthetic mRNA encoding tumor-… antigen-presenting cells antigen
presentation, and induce an … a more effective protective antitumor effect. Furthermore, our …

Bridging the gender gap in autoimmunity with T-celltargeted biomaterials

AL Ruiz, ED Slaughter, AM Kloxin… - Current Opinion in …, 2024 - Elsevier
… of synthetic particles enable artificial antigen-presenting cell (… to CD4+ T-cells and regulate
effector responses through only … to provide longer term protection against lupus. Furthermore, …

A Potent Cancer Vaccine Adjuvant System for Particleization of Short, Synthetic CD8+ T Cell Epitopes

X He, S Zhou, WC Huang, A Seffouh, MT Mabrouk… - Acs Nano, 2021 - ACS Publications
… immune responses at nanogram dosing. Along with CoPoP (… better taken up by antigen-presenting
cells, where they were … protection rate is in accordance to the Ag-specific CD8 + T

[HTML][HTML] Strategies to use nanoparticles to generate CD4 and CD8 regulatory T cells for the treatment of SLE and other autoimmune diseases

DA Horwitz, S Bickerton, A La Cava - Frontiers in Immunology, 2021 - frontiersin.org
T cell targeted nanoparticles have been formulated to act as tolerogenic artificial antigen
presenting cells… viruses and pathogens that elicit or subvert immune responses are, in essence, …

Synthesis of Dendritic Cell-Targeted Polymeric Nanoparticles for Selective Delivery of mRNA Vaccines to Elicit Enhanced Immune Responses

CH Wong - bioRxiv, 2023 - biorxiv.org
… delivery to antigen presenting cells to elicit enhanced broadly protective immune responses.
… mRNA vaccine to antigen-presenting cells (APCs) especially dendritic cells, we designed …